Locked-in syndrome (LIS) is one of the most dramatic neurological outcomes and has a profound impact on patients and their families. Most patients have intact cognition and intellectual ability and perception. Communication is possible with eyelid and/or eyeball movement. According to the literature, the wish to die is not an important issue in acute and chronic LIS. This study describes and analyses the ethical decision-making process in two opposite cases of LIS in the intensive care unit. One patient expressed the (...) wish to prolong her life for as long as possible; the other patient asked for deliberate termination of life. Both wishes were honoured. In conclusion, most patients with LIS are competent and intellectually intact. In The Netherlands the autonomy of the patient is respected by law. In respecting this autonomy, medical choices can be different in comparable patients. (shrink)

Introduction , Sophie Gibb 1. Mental Causation , John Heil 2. Physical Realization without Preemption , Sydney Shoemaker 3. Mental Causation in the Physical World , Peter Menzies 4. Mental Causation: Ontology and Patterns of Variation , Paul Noordhof 5. Causation is Macroscopic but not Irreducible , David Papineau 6. Substance Causation, Powers, and Human Agency , E. J. Lowe 7. Agent Causation in a Neo-Aristotelian Metaphysics , Jonathan D. Jacobs and Timothy O’Connor 8. Mental Causation and Double Prevention , (...) Sophie Gibb 9. The Identity Theory as a Solution to the Exclusion Problem , David Robb 10. Continuant Causation, Fundamentality, and Freedom , Peter Simons 11. There is no Exclusion Problem , Steinvor Tholl Arnadottir and Tim Crane. (shrink)

One currently popular methodology of metaphysics has it that ‘intuitions’ play an evidential role with respect to metaphysical claims. This chapter defends a realist methodology of metaphysics that implies that any rational being, simply in virtue of being rational, is necessarily capable of grasping the essences of at least some mind-independent entities. The notion of essence in play here is Aristotelian, whereby an entity’s essence is captured by an account of what that entity is, or what it is to be (...) that entity. Concepts are just ways of thinking of things and, as such, may or may not be adequate to the real natures — the essences — of the things being thought of. Our ‘intuitions’, particularly as revealed by aptly constructed thought experiments, may cast interesting light on some of our concepts, but they are not and cannot be reliable guides to mind-independent truths of essence. (shrink)

This chapter contains sections titled: The Syntax and Semantics of Complex Sortal Terms On the Identity of Sorts.

The relations between reason, motivation and value present problems which, though ancient, remain intractable. If values are objective and rational how can they move us and if they are dependent on our contingent desires how can they be rational? E. J. Bond makes a bold attack on this dilemma. The widespread view among philosophers today is that judgements contain an irreducible element of personal commitment. To this Professor Bond proposes an account of values as objective and value judgements as true (...) or false, employing a distinction between grounding and motivating reasons to establish their connection with action. He defines and tests his position against a number of recent theories, providing in the process forceful criticism of Williams, Wiggins, Foot, Narveson and Nagel, among others. A distinctive contribution to the subject, it will stimulate interest and worthwhile debate among philosophers, while also serving as an introduction to this vital topic. (shrink)

本书的论文展示了这位伟大的历史学家对研究历史的重要性热情洋溢的信念,以及深邃的分析、论说的广度和独到的见解,这些足以令他名至实归。.

As thinkers in the market for knowledge and agents aspiring to morally responsible action, we are inevitably subject to luck. This book presents a comprehensive new theory of luck in light of a critical appraisal of the literature's leading accounts, then brings this new theory to bear on issues in the theory of knowledge and philosophy of action.

Luck looms large in numerous different philosophical subfields. Unfortunately, work focused exclusively on the nature of luck is in short supply on the contemporary analytic scene. In his highly impressive recent book Epistemic Luck, Duncan Pritchard helps rectify this neglect by presenting a partial account of luck that he uses to illuminate various ways luck can figure in cognition. In this paper, I critically evaluate both Pritchard’s account of luck and another account to which Pritchard’s discussion draws our attention—viz., that (...) due to Nicholas Rescher. I also assess some novel analyses of luck that incorporate plausible elements of Pritchard’s and Rescher’s accounts. (shrink)

In “The Nature of the Atonement”, Eleonore Stump explores the problem of human sin that the atonement is meant to solve, helpfully uncovering important adequacy conditions for theories of atonement. She then uses those conditions to critically evaluate Anselmian and Thomistic theories of atonement, arguing (among many other interesting things) that the Thomist has a leg up on the Anselmian when it comes to the atonement-motivating problem of human sin (pp.11-12 of ms.). I argue for two claims in what follows. (...) First, Stump’s two seemingly independent “further problems” for theorists of atonement (discussed in the penultimate section of her paper) in fact reduce to a single challenge, which suggests a strategy for future theorizing about the atonement. Second, Stump’s case that the Thomist outperforms the Anselmian on the problem of human sin is weaker than it initially appears. As we’ll see, Stump’s own account of shame implies that the Anselmian’s difficulties on this front are less serious than she thinks. (shrink)

This chapter contains sections titled: The Varieties of ‘Is’ Individuals, Kinds, and Realism Semantics, Metaphysics, and Necessity New Developments.

This chapter contains sections titled: Appendix: An Axiomatic System of Sortal Logic.

This chapter contains sections titled: Matter and Organisms Organisms and Persons Is There a Criterion of Personal Identity?

This chapter contains sections titled: Appendix: Some Formal Principles and Arguments.

This theory accords to volitions the status of basic mental actions, maintaining that these are spontaneous exercises of the will--a "two-way" power which ...

Many philosophers hold that luck excludes control-more precisely, that an event is lucky for you only if that event lies beyond your control. Call this the Lack of Control Requirement (LCR) on luck. Jennifer Lackey [2008] has recently argued that there is no such requirement on luck. Should such an argument succeed, it would (among other things) disable a main objection to the "libertarian" position in the free will debate. After clarifying the LCR, I defend it against both Lackey's argument (...) and a novel argument different in kind from Lackey's. I undermine each of these arguments by sketching a plausible error theory for its key intuition. For each argument, there's a natural reply available to its proponents. I show that these natural replies depend on certain mistaken general principles about luck. Neither Lackey's argument nor the novel argument I consider casts serious doubt on the LCR. [Word count: 147]. (shrink)

This paper advances the debate over the question whether false beliefs may nevertheless have warrant, the property that yields knowledge when conjoined with true belief. The paper’s first main part—which spans Sections 2–4—assesses the best argument for Warrant Infallibilism, the view that only true beliefs can have warrant. I show that this argument’s key premise conflicts with an extremely plausible claim about warrant. Sections 5–6 constitute the paper’s second main part. Section 5 presents an overlooked puzzle about warrant, and uses (...) that puzzle to generate a new argument for Warrant Fallibilism, the view that false beliefs can have warrant. Section 6 evaluates this pro-Fallibilism argument, finding ultimately that it defeats itself in a surprising way. I conclude that neither Infallibilism nor Fallibilism should now constrain theorizing about warrant. (shrink)

The complex hexaploid wheat genome offers many challenges for genomics research. Expressed sequence tags facilitate the analysis of gene-coding regions and provide a rich source of molecular markers for mapping and comparison with model organisms. The objectives of this study were to construct a high-density EST chromosome bin map of wheat homoeologous group 2 chromosomes to determine the distribution of ESTs, construct a consensus map of group 2 ESTs, investigate synteny, examine patterns of duplication, and assess the colinearity with rice (...) of ESTs assigned to the group 2 consensus bin map. A total of 2600 loci generated from 1110 ESTs were mapped to group 2 chromosomes by Southern hybridization onto wheat aneuploid chromosome and deletion stocks. A consensus map was constructed of 552 ESTs mapping to more than one group 2 chromosome. Regions of high gene density in distal bins and low gene density in proximal bins were found. Two interstitial gene-rich islands flanked by relatively gene-poor regions on both the short and long arms and having good synteny with rice were discovered. The map locations of two ESTs indicated the possible presence of a small pericentric inversion on chromosome 2B. Wheat chromosome group 2 was shown to share syntenous blocks with rice chromosomes 4 and 7. (shrink)

Locke's main semantic thesis is that words stand for, or signify, ideas. He says this over and over again, though the phraseology he employs varies. In Book III chapter 2 alone we find the following statements of the thesis: ‘ … Words … come to be made use of by Men, as the Signs of their Ideas’ [III.2.1; 405:10-11); The use then of Words, is to be sensible Marks of Ideas; and the Ideas they stand for, are their proper and (...) immediate Signification’ [III.2.1; 405:15-17]; ‘Words in their primary or immediate Signification, stand for nothing, but the Ideas in the Mind of him that uses them’ [III.2.2; 405:21-2]; That then which Words are the Marks of, are the Ideas of the Speaker’ [III.2.2; 405:27-8]; ‘ …. (shrink)

This is the first full-length translation of a work by the influential medieval logician Walter Burley. As such, it is an important addition to our knowledge of medieval logic, and will undoubtedly spur further research.